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Both SIRT1 and SIRT6 are measurably downregulated in older skin, and this downregulation correlates directly with reduced NAD+ availability

Together with the electron-impact fragmentation pattern of each identified MCF derivatised 13 C-labelled metabolite, the degree of labelling was estimated based on the variation observed in the fragmentation pattern of 13 C-labelled metabolites in comparison to their counterpart 12 C mass spectrum

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Together, these data demonstrate that SREBP-1c mediates the induction of insulin lipogenic genes, but that SREBP-1c and ChREBP are both necessary for harmonious induction of glycolytic and lipogenic genes

Biochemical chemistry of thiols in the vasculature and in vascular-related disease