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Preclinical studies have shown a favorable safety profile, but more rigorous clinical trials are necessary to fully understand its potential side effects and risks

The transcription factor p53 also plays a dual role in melanocyte defense by upregulating tyrosinase, a key enzyme in melanogenesis, and enhancing the antioxidant response via the Nrf2 pathway 17 , but also it can stop the melanocyte cell cycle, even leading to apoptosis 79

Some of the side effects are uncommon but serious

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Reality: The effects are not permanent and may require maintenance doses to sustain skin brightness