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Gomisin J, another low-molecular-weight lignan from Schisandra , regulates lipogenesis and lipolysis by activating AMPK, LKB1, and Ca (2+) /calmodulin-dependent protein kinase II (CaMKII) in HepG2 cells, as well as inhibiting fetuin-A, thereby suppressing lipid accumulation (86)

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Updated 1/22/2011

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Rodents fed with HFD develop increased ovarian lipid accumulation, disrupted mitochondrial function, elevated ROS production, and chronic metabolic inflammation, closely mimicking PCOS and metabolic-related reproductive impairment (Gonnella et al., 2022)