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In addition, excessive ROS production can lead to oxidative stress, which in turn affects sperm nuclear DNA, sperm mitochondrial respiratory activity 40 and endocrine function, leading to a variety of male reproductive system disorders, and consequently may lead to male infertility 41,42

It was found that frequency of use is high, particularly in the upper grades: the prevalence of daily or almost daily e-cigarette use was 13% (133 000) among students in grades 10 to 12

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