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Amputation associated with heparin administration Heparin (10 mg/kg) was given intravenously at 30 minutes before the bleeding procedure

However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs

If an overdose is known to have occurred, treatment should focus on managing symptoms and providing supportive care

Although HMP is useful for organ preservation, it is difficult to assess organ viability during HMP because of the reduced metabolic activity at low temperatures, and the adoption of HMP has faced logistical challenges

Both methods are administered by a healthcare professional to ensure safety and efficacy