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For example, a bile acid metabolite (gut microbiome-derived glycochenodeoxycholic acid) activates the TFR/ACSL4 pathway to induce ferroptosis, promoting progression of environmental toxin-associated metabolic dysfunction-associated fatty liver disease (Liu et al., 2022a)

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Additionally, some species, such as Candida auris , acquire resistance genes from the environment and modify host conditions to favor survival (Akinbobola et al., 2023)

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