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Some common contaminants or impurities that can be found in low-purity peptides may include: Residual Solvents Peptide Fragments Microbial Contaminants Heavy Metals Some of the most reliable testing methods used to assess the purity and quality of pharmaceuticals are high-performance liquid chromatography and mass spectrometry [15, 16]

J Pharmacol Exp Ther 187:211217 Muldrew KL, James LP, Coop L, McCullough SS, Hendrickson HP, Hinson JA, Philip R, Mayeux PR (2002) Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection

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