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Macroscopically, a degenerated disc contains annulus fissures 8 , and/or endplate defects 9 , and microscopic changes include accelerated loss of water-retaining glycosaminoglycan (GAG) molecules 10 , nerve and blood vessel infiltration 11 , cell clustering 12 , and upregulation of matrix-degrading enzymes 13

J.YangG.FrancisD.et al (2019)

Not shown on the list because they are strictly oral are the collagen peptides which are widely marketed and not-FDA approved

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