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216 In addition, PRMT4-catalyzed asymmetric dimethylarginine (ADMA) has been reported to bind to NOS as a ligand, leading to NOS dysfunction, resulting in decreased cerebral blood flow and aggravating AD, which can be reversed by inhibition of PRMT4

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As part of the Progression of Liver Disease and Cardiovascular Disorders in Non-alcoholic Fatty Liver disease (PLINIO) study, soluble Nox2-derived peptide, a marker of systemic oxidative stress, and serum LPS, were higher in patients with overweight/obesity and correlated with low adherence to MedDiet ( n = 136) for 3 months