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Maintaining proper nutrition and supplementation helps support balance during treatment

The pool of free CoA-SH decreases, so that free mitochondrial carnitine stores cannot be restored from acylcarnitine (including valproylcanitine) under the action of CPT2

Respiratory quotient (RQ) is increased during dark phase in Insr P1195L/ + mice under both ND and HFD P1195L/ + The decrease in fat accumulation in WAT and liver of Insr P1195L/ +/HFD mice suggested that these animals may have increased energy dissipation and/or fat usage

Epidemiologically, the burden of ALS is rising worldwide

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