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Analysis of paired samples of GC tissue and adjacent normal mucosa revealed that the GC samples exhibited high ACTL6A and GCLC protein expression levels (Supplementary Fig

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This led some authors to propose a chaperone competition model, in which aggregates, client, and metastable proteins (polyQ, huntingtin, ATXN1, and superoxide dismutase-1) rival for finite chaperone resources [64]

Kanno et al., 2009) and autophagy (Kanno et al., 2009)