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If the solution appears cloudy, discolored, or contains visible particles, discard it regardless of how recently it was reconstituted

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The effect of PPIs is steadily reversed over time by both de novo synthesis of new proton pumps, and reduction of the disulfide bond between PPIs and the pump protein by endogenous parietal cell glutathione (GSH), estimated to exist at an intracellular level of ~3 mM (Figure 2) (Shin & Sachs, 2008)

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