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Overall, the decrease of total macrophage population and M2 subphenotype excluded the macrophages polarization from the pathway enrichment after CD5/ LNP-FAPCAR 2.2 treatment

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Preclinical and clinical studies demonstrate that co-administration of these peptides achieves superior reductions in bodyweight, appetite, and fasting glucose than either agent aloneachieving up to a 17% reduction in bodyweight in non-diabetic individuals and a 15.6% reduction in patients with type 2 diabetes over 2032 weeks

10.1038/s42003-024-05849-8