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However, excessive BCACs produced by the breakdown of branched-chain amino acids can interfere with normal mitochondrial function and cause energy metabolism disorders [11]

For instance, purified NETs increased endothelial permeability and raised surface expression of Eselectin, ICAM1, VCAM1, as well as TF activity in human umbilical vein endothelial cells (HUVECs) [80]

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Some studies have also investigated the peptides relationship with growth factor signaling and inflammatory mediators that participate in tissue remodeling

Mucosal Immunol (2012) 5(4):35466