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In comparison to arbutin, LEVs showed a more effective inhibitory effect on melanin synthesis in a human epidermal model

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doi: 10.1038/sj.onc.1209576

Additionally, cAMP/PKA signaling rapidly mobilizes GH-containing secretory granules and promotes their fusion with the plasma membrane, causing acute release of stored GH into the hypophyseal capillaries that drain into systemic circulation