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PiperinePiperine is an alkaloid extracted from black pepper that has the unique ability to enhance the transdermal absorption of other substances, primarily through the following mechanisms: altering the skin barrier (stratum corneum), inhibiting drug metabolism, and increasing cell membrane fluidity

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These events could combine a threatening chain of events until the final harm [1]: angiogenesis carcinoma, VEGF carcinoma

74 However, because these results were never formally published in peer-reviewed journals, they have to be taken with caution

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