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A glycine-insulin autocrine feedback loop enhances insulin secretion from human -Cells and is impaired in type 2 diabetes
doi: 10.3389/fendo.2023.1162445 Received 09 February 2023 Accepted 05 April 2023 Published 20 April 2023 Volume 14 - 2023 Edited by Benjamin Samuel Weeks, Adelphi University, United States Reviewed by Wei Peng, Chengdu University of Traditional Chinese Medicine, China
Larger, longer-term trials in healthy adults are underway, but they have not yet produced final conclusions
Dose-ranging studies of AA administration in DIO mice under AL feeding revealed a significant elevation in AA levels in the hypothalamus starting at 7.5 mmol/kg, with a greater increase observed at 15 mmol/kg (Supplementary Fig
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