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Figure 2 A fundamentally important debate in the field revolves around the outside-in (whereby a primary defect in the peripheral immune system promotes invasion of the CNS by autoreactive immune cells) vs

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In CLL, a higher OCR is associated with prognostically unfavorable factors such as advanced stage, unmutated IGHV status, ZAP-70 positivity, and high level of 2-microglobulin as well as development of drug resistance (17) and an increased risk of Richters transformation (38)

Mechanistically, we showed that system x C blockade in conjunction with APR-246, synergistically depleted intracellular GSH, resulting in mitochondrial ROS accumulation, lipid peroxidation and ultimately apoptotic cell death (Fig

Reaction termination involves reactions of two free radicals to form nonfree radical end products