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Cigarette tobacco is explicitly fire-cured and chemically enhanced to be inhaled, meaning it lacks the sodium carbonate buffers required to balance oral pH levels, which results in a highly inefficient nicotine transfer and extreme gum irritation

Abstract Nicotine and tobacco use are more common among orthopedic trauma patients than in the general population and have significant implications for pain management and recovery outcomes

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Since prehistoric times, people have recognized the stimulating effects of the smoke created by burning tobacco, and smoking has become the most common form of nicotine uptake ever since