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These compounds have the ability to neutralize ROS without transforming into deleterious radicals themselves (Zandi and Schnug, 2022)

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N-acetyl cysteine (NAC) is the current standard of care for APAP overdose 12 , which is It is believed to have benefit in APAP hepatotoxicity by increasing the availability of the glutathione precursor cysteine, thereby driving glutathione synthesis

Its history is best read not as a single discovery event but as the endpoint of roughly two decades of medicinal chemistry that began with an accidental observation about opioid analogs and ended with a compound engineered for receptor selectivity