The problem occurs when we are bombarded with oxidative stress and toxins
10.1152/japplphysiol.90525.2008 Summary Keywords optimizing supplementation, muscle carnosine content, metabolism, buffering, modifying factors Citation Perim P, Marticorena FM, Ribeiro F, Barreto G, Gobbi N, Kerksick C, Dolan E and Saunders B (2019) Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized
This shows that hypertension leads to iron overload in the brain, and iron overload increases OS and lipid peroxidation, thereby causing ferroptosis (Yang et al., 2020) in neurons and ultimately leading to brain injury (Figure 2)
When transplanted into a murine stroke model, iPSC-derived pericytes could successfully improve neurological function and BBB integrity [332]
Energy and metabolism improvements happen because glutathione protects your mitochondria - cellular powerhouses