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Thus, our comparative genomic analyses illustrate that the fundamental functions of antioxidants have resulted in gene conservation throughout the animal kingdom, paving the way for functional analyses on these enzyme families in diverse animal phyla

The inhibition of NF-B by zinc via A20 and PPARs signaling pathways are the most important mechanism because zinc decreases pro-inflammatory cytokines in atherosclerosis [35]

7.1 Future implications Despite the growing body of evidence linking gut microbiome dysbiosis to the pathophysiology of PCOS, several important questions remain unresolved

doi: 10.1016/j.neuropharm.2018.08.004 40

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