Poster Session II - PRE-HOSPITAL SERVICE ORGANISATION 09.00 - PRE-HOSPITAL SERVICE ORGANISATION - 09.01 - PRE-HOSPITAL SERVICE ORGANISATION P797 - ESOC25-1744 CO-DESIGN OF A MOBILE STROKE UNIT PATHWAY HIGHLIGHTS UNCERTAINTIES AND TRADE-OFFS FOR VIABLE SYSTEM-WIDE IMPLEMENTATION IN THE ENGLISH AND WELSH NHS Jason Scott 1 , Lisa Moseley 2 , Michael Allen 3 , Gary Ford 4 , Martin James 3 , Anna Laws 3 , Stephen McCarthy 1 , Graham McClelland 1 , Kerry Pearn 3 , Daniel Phillips 5 , Chris Price 2 , Lisa Shaw 2 , Philip White 2 , Dave Wilson 6 , Peter McMeekin 1 1 Northumbria University, Newcastle upon Tyne, United Kingdom, 2 Newcastle University, Newcastle upon Tyne, United Kingdom, 3 University of Exeter, Exeter, United Kingdom, 4 University of Oxford, Oxford, United Kingdom, 5 East of England Ambulance Service NHS Trust, Melbourn, United Kingdom, 6 Stroke Service User Voice Group, Newcastle upon Tyne, United Kingdom Background and Aims: Benefits of Mobile Stroke Units (MSUs) have been demonstrated but are context dependent
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p53 tumour-suppressor caution Because FOXO4-DRI intervenes in the p53 pathway, which is critical for tumour suppression, there is theoretical concern that interfering with p53 dynamics might carry oncogenic risk
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