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It was first characterized by Professor Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s

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Struggling with pigmentation, wrinkles, or dull skin

These mtDNA-depleted (Rho-0) cells showed the expected reduction in COX I, a mitochondrial genome-encoded protein, and also lacked detectable rHN peptide, strongly supporting its mitochondrial origin [2]