Randomized trials that isolated B12 tend to be small or combine the vitamin with other agents, making causal claims weak
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In this regard, close attention should be paid to better understanding of clinical cases of AD reversal achieved in complex targeted interventions that include a mix of sleep, exercise and diet optimization, copper/zinc balancing, heavy metal chelation, hormone balancing, GI tract repair and oral hygiene improvement (Bredesen, 2014
This is often associated with exhaustion, poor strength of grip or involuntary weight loss due to mitochondrial dysfunction caused by L-Carnitine deficiency
In the context of ME/CFS and Long COVID, where glucose metabolism is often dysregulated and insulin resistance can develop, the ability to efficiently burn fats for energy becomes paramount