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doi: 10.1007/BF02910407 95

& Collins, J

Pharmacotherapy 37, 261267

Taken together, these pieces of evidence suggest that the biosynthesis rate of glutathione might be involved in nephrotoxicity by increasing cellular retention of Hg, altering the redox balance and leading to cytotoxicity 46,47 , possibly via mitochondria dysfunction by altering the ratio of reduced (GSH) to oxidized (GSSG) glutathione in this organelle 48,49