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The Phase 2 SHAPE trial (NCT04831281) in Parkinsons disease dementia and dementia with Lewy bodies failed its primary endpoint in December 2023

What has changed in recent years is the pace and scope of research

Abstract Background: Pichia pastoris -secreted delta sleep inducing peptide and crossing the blood-brain barrier peptides (DSIP-CBBBP) fusion peptides holds significant promise for its potential sleep-enhancing and neurotransmitter balancing effects

Experimental Eye Research, 2005

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