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These findings indicate that the most affected component of OXPHOS in ASD patients is complex I, but abnormalities in the activity of other complexes, such as complexes III, IV, and V, can also be found

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La baisse du GSH est la fois une consquence et un amplificateur du vieillissement : l'accumulation de dommages oxydatifs rduit la capacit de synthse, tandis que la dpltion en glutathion laisse les cellules plus vulnrables aux agressions suivantes

[ 478 ] Especially in the MPTP mouse model of Parkinson's disease, only the pretreatment with NRF2 activators provides protection, not the posttreatment