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Acute dopamine depletion model in SD rats This protocol was adapted and modified from McDougall et al

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Swim latency, swim distance, time spent in the target quadrant, and number of quadrant crossings were recorded using a computerized video tracking system [2]

It kills any kind of cells regardless of the expression of c-Met protein, and the cytotoxicity of tivantinib is related to inhibit microtubule assembly ( Cabozantinib is a novel small-molecule multi-target tyrosine kinase inhibitor of c-Met, VEGFRs, RET, KIT, and AXL (Yakes et al., 2011)

Abstract Alterations in excitatory neurotransmitters, involving the glutamate (Glu) and glutamine (Gln) cycle, as well as inhibitory neurotransmission, GABA, are implicated in the pathophysiology of autism spectrum disorder (ASD)