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Most patients experience appetite reduction and early weight loss within 2-4 weeks of starting therapy

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If they notice less bloating and other symptoms, such as sniffling, sneezing, headaches, rashes, diarrhea, abdominal pain, or itching, they may have discovered a histamine intolerance

Initially described as a pro-atherogenic molecule due to its proliferative role in VSMC, it was further demonstrated that the effect of IGF-I on VSMC was to compensate for local apoptosis, and that, overall, IGF-I is not pro-atherogenic in native arteries but anti-atherogenic[320], mainly through enhanced nitric oxide production[308]