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Our findings reveal significant alterations in glycogen metabolism, glycolysis and lipid storage, combined with alterations in mitochondrial properties characterized by increased maximal respiratory capacity without changes in basal oxidative phosphorylation, all of which associated with the pathophysiology of PRKAG2 cardiomyopathy

Three or four vials for Phase 3 and Phase 4 gets expensive and wasteful since each vial has solution remaining after the last needed draw

Abbreviations AP: Acute Pancreatitis CP: Chronic pancreatitis SAP: Severe acute pancreatitis GC-MS: Gas chromatography-mass spectrometry AST: Aspartate Aminotransferase ALT: Alanine Aminotransferase GGT: Gamma-Glutamyl Transferase BUN: Blood Urea Nitrogen ALP: Alkaline Phosphatase CREA: Creatinine HE: Hematoxylin and Eosin ELISA: Enzyme-Linked Immunosorbent Assay HIF-1: Hypoxia-inducible factor 1 alpha VEGF: Vascular Endothelial Growth Factor PCoA: Principal Coordinates Analysis OPLS-DA: Orthogonal partial least squares discriminant analysis DEMs: Differential metabolites CI: Cerulein TNF-: Tumor Necrosis Factor-alpha IL-6: Interleukin 6 IL-1: Interleukin 1 beta MSP: Methylation-Specific PCR (Polymerase Chain Reaction) mTOR: Mammalian Target of Rapamycin p-mTOR: Phosphorylated Mammalian Target of Rapamycin NMDS: Non-metric Multidimensional Scaling References Lankisch PG, Apte M, Banks PA

It is well-known that alcohol exacerbates the progression of AP [33]