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1 Introduction Autoimmune disorders represent a prominent class of pathologies defined by a breakdown in self-tolerance, where a dysregulated immune system attacks host tissues, thereby initiating localized or systemic inflammatory damages (6)

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Furthermore, the fact that tracer retention in cortical regions increased with clinical disease severity, as estimated by the Revised ALS Functioning Rating Scale (ALSFRS-R), suggested that OS may be an important factor associated with the development of neurodegeneration in ALS patients [107]

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