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Gastroenterology 167, 11831197.e16

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This reduces production of IL-1, IL-6, TNF-, and other cytokines driving chronic oral inflammation

Indeed, evidence in mice has shown that supplementation of L-malate increased the activity of malate dehydrogenase (MDH) in a doseresponse manner, as higher doses reported more activity (Control mice: 15.7 2.4 vs

For example, mesenchymal-specific TNFR1 triggering is indispensable for arthritis development in acute and chronic TNF-dependent mouse models