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demonstrated that iron overload triggers ferroptosis in MC3T3-E1 cells, a murine osteoblast cell line, and that this process is attenuated by ferroptosis inhibitors ( Figure 3 Osteocytes Osteocytes are terminally differentiated osteoblasts embedded within the bone matrix, and they are the most abundant cell type in mineralized bone, playing a central role in maintaining skeletal homeostasis ( The role of HO-1 in osteocyte ferroptosis is context dependent

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