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In our studys limitations, we acknowledge the relatively modest sample sizes for African, East Asian, Admixed American/Latino, and Middle Eastern populations, which may hinder the robustness of our GWAS findings in diverse ancestries

Mass spectrometry (LC-MS) identity confirmation

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However, the TRIP12-dependent K29-linked ubiquitylation of OTUD5 was partially decreased by UBR5 knockdown, whereas TRIP12-dependent increase of K48-linked chains was massively diminished by UBR5 knockdown (Fig

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