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Diphthamide biosynthesis genes are essential to normal development, and deletion of these genes in mice leads to developmental defects including embryonic lethality, while mutations found in humans are associated with developmental delays, intellectual disability, craniofacial and genital abnormalities (Nakajima et al, 2018)

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The extent to which the mechanisms responsible for this decline are evolutionarily conserved remains unclear

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Even moderate activities like walking, swimming, or yoga can make a difference