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Glutamine-mediated epigenetic regulation of cflip underlies resistance to trail in pancreatic cancer

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doi: 10.1016/j.bbamcr.2012.01.005 47 CoppsKWhiteMJD

Oxidative stress and disturbance of endoplasmic reticulum calcium metabolism may disrupt endoplasmic reticulum homeostasis, leading to endoplasmic reticulum stress, which then induces the unfolded protein response (UPR) to adapt to these changes