doi: 10.1042/bj2200553 Middlehurst, CR, King, GF, Beilharz, GR, Hunt, GE, Johnson, Gfs and Kuchel, PW (1984)
The digestive enzymes within lysosomes function optimally at an acidic pH, meaning they require a permanent supply of protons
This hepatic effect operates through glucagon receptor activation and has implications for anyone studying metabolic syndrome comprehensively
It is also not metabolized in the intestines like arginine is
This study was supported by National Key R&D Program of China (2023YFC2509100), Science and Technology Commission of Shanghai Municipality (23Y31900400), National Natural Science Foundation of China (82370984 & 82370980), Natural Science Foundation of Shanghai (22ZR1437600), Shanghai's Top Priority Research Center (2022ZZ01017), and Dominant disease biological sample project of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (YBKA202201)