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(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates

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These results suggest that acrolein resistance may be associated with higher glutathione production, though this relationship does not hold under all conditions

(PubMed) Breithaupt-Grogler K, Niebch G, Schneider E, et al