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Functionalization of 3-PLG with l-alanine and l-glutathione The A-GSH-targeted 3-PLGs (3-PLG-A-GSH) were synthesized by grafting A and GSH on 3-PLG using N -ethyl- N -(3-(dimethylamino)propyl)carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling reaction in DIW (Fig

Collagen targeting peptide (T ECM ) was prepared by automated solid-phase peptide synthesis at a 100 mol scale on a rink amide resin using standard Fmoc-based protocols 30 (Supplementary Fig

The concentration of vitamin C in plasma is approximately 50 M

Abbreviations: DMPFC, dorsomedial prefrontal cortex

long-term BPC-157 use carries unquantified risk until prospective human trials establish pharmacokinetics and toxicity thresholds across extended timeframes