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10 Environmental Exposures Epidemiologic studies and animal experimental models have identified an association between PD and the following environmental risk factors: rural residence, farming, well-water drinking, exposure to pesticides (including organochlorines, carbamates, paraquat, maneb, rotenone, and diethyldithiocarbamate), and long-term occupational exposure to copper, iron, lead, and manganese

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AMPK and mTOR are highly expressed in the brain and interconnected mutually in the regulation of energy balance and homeostasis (Li et al