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Most insurers want proof that the anemia is real and properly evaluated

Leary told Glossy

The standard approach often begins with a low dose of semaglutide, commonly 0.25 mg weekly for the first four weeks, which serves primarily as an initiation dose to allow physiological adaptation rather than providing significant therapeutic effect

Injectable protocols provide systemic exposure that may benefit skin through internal mechanisms

Retatrutide achieved up to 24.2% body weight reduction over 48 weeks in the Phase 2 trial published in the New England Journal of Medicine , which involved adults with obesity but without diabetes