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Production of IFN- and IL-17A is decreased in T-cells lacking RA signaling and Th17 cells are severally reduced in vitamin A deficient mice (23)

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At the onset of the psoriatic cascade, interferon- has a role in promoting the production of CCL20, IL-17 + T cells, and -defensin2 (HBD-2), which is a protein that is both antimicrobial and chemotactic in nature