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Intramuscular (IM) GSH has been utilized in clinical settings to support systemic redox balance in patients undergoing chemotherapy, individuals with HIV/AIDS, and in the treatment of male infertility (55)

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This regulatory relationship is inversely validated at the molecular level: the GPX4 inhibitor RSL3 potently induces ferroptosis by binding to its active site, serving as a reliable experimental tool for studying ferroptosis in AD and directly establishing a causal link between GPX4 inhibition and AD pathology (191)

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts