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The DISC activates caspase 8 (CASP8) or caspase 10 (CASP10) and downstream executioner caspase cascades

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Thus, timing matters avoid initiating during active wound repair phase

This article is for educational purposes and does not replace a medical evaluation

Tumor necrosis factor-alpha induces transforming growth factor-beta1 expression in lung fibroblasts through the extracellular signal-regulated kinase pathway