Furthermore, some types of epilepsy are associated with the up-regulation of the mTOR pathway, and inhibition of this pathway by AMPK activators such as metformin can reduce seizure frequency and severity (Kim et al
Nature 465 , 937941 (2010)
This line of research directly informed the development of Dihexa
( mRNA quantification by quantitative real-time PCR (qRT-PCR) Total RNA was isolated using QIAzol-Reagent (Qiagen, Germany), based on modified Chomczyski & Sacchis method (Chomczynski and Sacchi, 2006), following the manufacturers protocol
Initially investigated for its potential to treat neurodegenerative diseases like Alzheimers and Parkinsons, this small synthetic peptide is known to bind with high affinity to hepatocyte growth factor (HGF) and its receptor c-Met, thereby promoting neuronal differentiation, dendritic branching, and synaptic plasticity