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Fundamental Concepts in Periodontal Regeneration It is important to underline the success of periodontal regeneration depends on several factors such as biofilm level, residual bleeding on probing, systemic conditions, smoking status, defect morphology, tooth mobility, early and late wound stability, type of biomaterials, choice of flap design and surgical skills of the clinician [23,24,25,26,27,28,29]

Proline Proline, a nonessential amino acid with a distinctive secondary amine group, is an important component of extracellular matrix (ECM) proteins

Vitamin B12 is a water soluble vitamin and helps the body to properly form red blood cells, grow tissues, and replicate DNA

437 The resulting increase in cGPDH activity promotes NAD regeneration and maintains cellular energy metabolism

A special care was taken to preserve the gallbladder