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Urology 70 , 463468 (2007)

Likewise, nicotine but not nicotinic acid is an agonist of the nicotinic receptors that respond to the neurotransmitter, acetylcholine

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Amino acid metabolism in DKD exhibits paradoxical effects: while BCAAs activate mTORC1 signaling leading to insulin resistance and podocyte injury, sulfur amino acid-derived H 2 S confers renoprotection through Nrf2 activation, whereas homocysteine accumulation promotes vascular damage (Figure 3)