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Because Tac binding to red blood cells is temperature sensitive as well as nonlinear, and the uptake by red blood cells is strongly dependent on FKBP concentration, it is practically difficult to separate full blood from plasma Tac (72)

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Complications associated with subcutaneous injections include abscesses and, in patients who require frequent injections, there is a risk of lipohypertrophy

Moreover, ROS can impair the epithelial barrier by disrupting the mucus layer, a protective barrier on the intestinal epithelial surface composed of mucins such as MUC2 secreted by IECs

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