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It has been well established that Abeta, when incubated with copper and oxygen, produces H 2 O 2 , while reducing Cu 2+ to Cu 1+ , during the period when it slowly transforms into soluble oligomers ( 2 O 2 , levels decrease, suggesting that the fibrils that are ultimately formed may clear the H 2 O 2

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Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes synovial joint inflammation as well as bone destruction and erosion, typically characterized by joint pain, swelling, and stiffness, with complications and persistent pain after remission posing a significant health burden for RA patients